Thermal Rearrangement - Continuous Flow Case Study
CASE STUDY: Thermal Rearrangement - A Continuous Approach
Thermal rearrangement of 7.5 kg of an API intermediate – A technically challenging and labour intensive process in batch with a typical yield of 50% and a poor impurity profile. Reaction conditions: Diphenyl ether, 180°C, 2 hours (followed by acid-base extraction and solvent switch into dichloromethane then ethanol).
The process was run continuously using a coil reactor and superheated ethanol as solvent. The yield and purity of the product were increased. The overall throughput was improved due to a shortened residence time and the number of human manipulations was reduced.
As a result the implementation of flow led to significant time and cost savings.
SMi Highly Potent Active Pharmaceutical IngredientsThe SMi Highly Potent Active Pharmaceutical Ingredients Conference will be attended by Mark Anstiss, Scale-up Chemist.
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66th Annual ASMS ConferenceThe 66th ASMS Conference on Mass Spectrometry and Allied Topics Conference will be attended by Michael Blackburn, Method Development Scientist (Physiochemical). Michael will also be presenting during the conference, at the Proteins & Peptides Waters Users Meeting, with a presentation entitled; A Powerful Hybrid IA-LC-MS/MS Method Quantification of Insulin Analogues and
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2018 BIO International ConventionThe 2018 BIO International Convention will be attended by Mark Chadwick, Head of Business Development.
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