Case Studies

Thermal Rearrangement - Continuous Flow Case Study

CASE STUDY: Thermal Rearrangement - A Continuous Approach


Thermal rearrangement of 7.5 kg of an API intermediate – A technically challenging and labour intensive process in batch with a typical yield of 50% and a poor impurity profile. Reaction conditions: Diphenyl ether, 180°C, 2 hours (followed by acid-base extraction and solvent switch into dichloromethane then ethanol).


US Biotech 


The process was run continuously using a coil reactor and superheated ethanol as solvent. The yield and purity of the product were increased. The overall throughput was improved due to a shortened residence time and the number of human manipulations was reduced.               

As a result the implementation of flow led to significant time and cost savings.


API Continuous Approach Case Study Pic

Continuous flow case study