Arcinova receive grant for continuous processing technology
Arcinova has announced the award of a £1.5 million Innovate UK grant for the development of new flexible modular manufacturing technologies; a project which is set to demonstrate the operating feasibility of world first innovative continuous production tools.
The project, which will span a three-year period, will be undertaken in collaboration with a team led by Professor Mike George, with Professors Pete Licence and Sir Martyn Poliakoff at the University of Nottingham.
The aim of the project is to develop a continuous, flexible modular manufacturing technology platform which will enable Arcinova to handle increasingly complex chemistries with more discreet manufacturing steps.
The platform will be used in manufacturing operations where manufacturing inventories need to be kept low and product purity needs to be maximized, where manufacturing throughput and efficiency are maintained at a high level and equipment changeover can be rapidly facilitated to cope with low batch numbers.
The project outcome is set to position Arcinova as a world leader in defining continuous modular manufacturing technology for the support of new chemical entities (NCEs) development, scale up and manufacture.
The developed continuous modular manufacturing technology will be easily scalable, with a reduced manufacturing footprint when compared to more traditional, batch reactor approaches. The developed technologies will enable Arcinova to enhance manufacturing capacity and minimise inventories for highly reactive hazardous processes whereas for a batch process the reaction scale would be severely constrained
Arcinova is a leading provider of drug substance process development and scale up support for a global client base and has inherited a site which has been operating for over 30 years with a wealth of process chemistry, safety, engineering and manufacturing support skills and infrastructure, both in batch and continuous manufacture.
The developed flexible modular manufacturing technology platform will enhance our existing infrastructure in GMP and non GMP assets, which include 5-litre and 20-litre GMP vessel streams, and build on its current capabilities in continuous processing technology.
Ian Shott CBE, CEO of Arcinova said: “I have spent over 20 years championing the way that pharmaceuticals are manufactured in the UK and have been an enthusiastic advocate for new manufacturing technologies including continuous manufacturing and synthetic biology as enablers for new and radically different pharmaceutical production approaches.
“This focus on improving productivity is laid out in the 2017 whitepaper on UK Industrial Strategy. I was delighted to learn of our successful Innovate UK grant which will enable Arcinova to offer a compelling, innovative and simplified route to high grade pharmaceutical manufacture.”
Mike George, Professor of Chemistry at the University of Nottingham, said: “My colleagues and I at Nottingham are firmly convinced that flow chemistry can transform chemical manufacture in the UK and this partnership with Arcinova is an opportunity to turn our vision into reality.”
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